It’s All In Your Head” explores the critical role of neurotransmitters (NTs) in individuals with scoliosis, highlighting how imbalances in these chemical messengers can significantly influence the onset, progression, and emotional toll of scoliosis. The focus is on four key neurotransmitters—dopamine, serotonin, norepinephrine, and histamine—each of which is tied not only to mood and cognition but also to genetic variants and metabolic pathways that impact scoliosis-related symptoms and comorbidities.