This comprehensive work by Dr. Clayton J. Stitzel explores how scoliosis, particularly Adolescent Idiopathic Scoliosis (AIS), is uniquely affected by female biology across three major hormonal milestones: puberty, pregnancy, and peri-menopause—the “3 P’s” of scoliosis progression. Unlike earlier views that framed scoliosis solely as a spinal issue, this modern perspective frames AIS as a systemic condition involving genetics, hormones, brain chemistry, neuromuscular control, and lifestyle—each of which evolves with the female lifecycle.